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If an investigator or instructor needs to modify an IBC approved protocol, a Protocol Modification Request form must be submitted to the Biosafety Office for review. Changes in project personnel, as well as significant changes to methods or the biological materials to be used subsequent to initial IBC approval must be approved by the IBC. Also, if additional research facilities will be utilized or the project will be moved to another laboratory, a Protocol Modification Request form needs to be submitted to the Biosafety Office. The Biosafety Officer, on behalf of the IBC, will review the proposed changes to determine if the changes alter the risk and/or biosafety level assessment. Subsequent review by the IBC may be required.