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OSU Laboratories at Venture I
OKLAHOMA TECHNOLOGY AND RESEARCH PARK
ENZYMOLOGY AND TOXICOLOGY LABORATORY
DR. GUANGPING CHEN
Dr. Guangping Chen’s research laboratory investigates phase I and phase II drug metabolizing enzymes, specifically focusing on sulfotransferases. Research areas include toxicology, pharmacology, biochemistry, and molecular biology. We are interested in the metabolism of hormones and important clinical drugs by human sulfotransferases; protein structure and function relationships; and the unique catalytic mechanisms of sulfotransferases. We are also investigating gene regulation mechanisms of drug metabolizing enzymes by hormones, cancer drugs, and bioactive food components; the relationships between various stressors and drug metabolizing enzyme functions during physical stress, chemical stress, oxidative stress, and neurological stress; the potential roles of sulfation in hormone-sensitive cancers and potential flavonoids which can be developed into novel breast cancer drugs.
EUGENE V. BENTON RADIATION PHYSICS LABORATORY
The Eugene V. Benton Radiation Physics Laboratory (EVBRPL) at Oklahoma State University is involved in a broad range of research concerning ionizing radiation and its effects on matter, especially as it relates to human health and safety. Current research areas include:
the radiation protection and dosimetry of humans in space and at aviation altitudes,
the assessment of the contribution of secondary neutrons to absorbed dose received by cancer patients during x-ray, proton, and carbon radiotherapy,
- the role of secondary cosmic ray electrons and muons in the initiation of lightning,
One major effort currently underway is the development and testing of multifunctional materials for use in radiation shielding of future spacecraft and planetary surface habitats. The laboratory is also actively involved in the development, characterization and testing of active and passive radiation detectors, including tissue equivalent proportional counters, for use in space, in the atmosphere and for ground-based applications including medical physics, health physics, and radiation science education.
MOLECULAR DIAGNOSTICS AND BIOSENSOR TECHNOLOGY LABORATORY
DR. JERRY MALAYER
The laboratory is involved in basic and applied research aimed at development of biosensor technology for detection of molecular targets, including targets specific to agents involved in biowarfare/bioterrorism, contamination of food products, and antibiotic resistant infections; characterization of mechanisms and processes employed to modify bacteria, including resistance to the effects of therapeutic antibiotics; and the development of platform technology for multi-locus assay of biosignature or biomarker targets for molecular diagnostic applications. These programs have applications in food safety and agricultural bioterrorism defense, as well as medical diagnostic and biosurveillance applications.
MOLECULAR MICROBIAL ECOLOGY LABORATORY
Dr. Elshahed’s laboratory at OSU studies the phylogenetic diversity, metabolic capabilities, and ecological roles of microorganisms in a variety of environments with specific emphasis on anaerobic habitats and soil. An integrative approach that combines large-scale, culture-independent phylogenetic surveys, environmental genomic (metagenomic) approaches, and isolation and characterization of novel microorganisms is used to study an ecosystem and/or a microbial group of interest.
The Elshahed group also studies various aspects of the ecology, biochemistry, evolution, and genomics of anaerobic fungi. Of special interest is the use of anaerobic fungal isolates or enzymes for efficient sugar extraction and biofuel production from lignocellulosic biomass. Our current efforts span a wide range of approaches, ranging from the isolation and characterization of novel anaerobic fungal strains, development of anaerobic fungal enzyme cocktails for lignocellulosic biomass deconstruction, and development of new consolidated bioprocessing schemes for biofuel production from ligncoellulosic biomass using anaerobic fungi.
Dr. Youssef’s lab is interested in exploring the metabolic diversities in single cell genomes of not-yet cultured Bacteria and Archaea. We analyze single-amplified-genomes (SAGs) of candidate phyla in hopes of finding clues for culturing them. Examples of SAGs studied include the candidate bacterial phyla WS3 "Latescibacteria," and WWE1 "Cloacimonetes," and the candidate archaeal superphylum DPANN.
The Youssef group is also interested in studying the evolutionary history of the Neocallimastigomycota, the fungal phylum of the anaerobic gut fungi (AGF). Currently we are conducting a pan genomic survey of all 6 known AGF genera, and utilizing the data for an extensive phylogenomic analysis of this phylum, especially for resolving the evolutionary history of Neocallimastigomycota within the fungal tree of life.
OSU MICROSCOPY LABORATORY
MS. LISA WHITWORTH
MR. BRENT JOHNSON
Established in 1977 on the OSU campus, the laboratory is a service and teaching facility that serves over 300 researchers and students from the various OSU colleges as well as clients from several companies in the Stillwater area, other parts of the state and across the U.S. Relocated to Venture I in January 2006, the laboratory continues to serve its users while expanding its services with new equipment and technologies. A list of these services and charges is available at http://www.microscopy.okstate.edu/fee.htm.
The laboratory houses both scanning and transmission electron microscopes equipped with digital imaging and x-ray microanalysis capabilities. These instruments show the visualization of structures at very high magnifications and with ultra-high resolution, down to nanometers (one billionth of a meter). With the addition of x-ray analysis capability, the elemental composition of these structures can be determined.
- Instruments include a JEOL JEM-2100 transmission electron microscope with an EVEX
X-ray microanalysis system, an FEI Quanta 600 FEG scanning electron microscope with
an EVEX X-ray microanalysis system, a Leica SP-2 confocal microscope, and a Veeco
- The transmission electron microscope enables imaging of the internal features of samples
whereas the scanning electron microscope shows the surface features of samples at
high power and resolution.
- The environmental scanning electron microscope allows the observation of samples in
their native or ‘wet’ state avoiding the artifacts introduced by chemical fixation,
dehydration and metal coating. It also has x-ray microanalysis capabilities as well
as the ability to obtain backscattered electron diffraction patterns to further characterize
the chemical nature of samples.
- Confocal microscopy localizes different macromolecules, organelles or structures within
samples using fluorescent dyes and can be used to make 3-D images and movies.
- The scanning probe (atomic force) microscope provides images of 3D surface topography at resolutions approaching the atomic or molecular scale as well as the chemical and physical properties of the surface of samples.
The laboratory offers instruction in microscopy techniques via a graduate course offered once per year and on an individual basis when needed. Outreach activities include the Oklahoma Microscopy Society “Ugly Bug” contest for elementary school students across the state, participation in art class projects with both OSU and Stillwater Junior High students and tours of the facility for local community groups. Tours are available upon request.
OSU RADIATION PHYSICS TEACHING LABORATORY
The OSU Radiation Physics Teaching Laboratory supports the radiation physics and medical physics programs at OSU by providing students with hands-on experience in a variety of instrumentation and techniques used in the detection, measurement and analysis of ionizing radiation. Beginning students carry out experiments to learn the basic techniques of radiation detection and measurement, while more advanced students are able to design and conduct their own experiments. Instrumentation includes survey meters, ionization chambers and proportional counters, liquid scintillation counters, and several alpha, beta, and gamma spectrometers. The laboratory also houses a collection of vintage radiation detectors spanning the history of radiation physics, as well as vintage physics demonstration apparatus. Historical items include several electroscopes, civil defense radiation detectors, and a 1930s vintage General Electric diagnostic x-ray machine. The laboratory also houses a cosmic ray muon spark chamber for demonstrating the presence of cosmic radiation at the Earth’s surface.
RADIATION DOSIMETRY LABORATORY
DR. STEPHEN W. S. MCKEEVER
DR. SERGEY SHOLOM
This long-established OSU lab conducts basic and applied research into luminescence materials and methods for the detection and measurement of radiation. The lab specializes in particular in thermally and optically stimulated luminescence, with applications in space dosimetry, medical, personal and environmental dosimetry. Additional interests are in retrospective dosimetry methods, especially methods for emergency dosimetry following accidents or other large-scale exposure events. Interests also include charged particle dosimetry, homeland security and dosimetry for radiation therapy.